De SEGA Mega Drive Ultimate Collection bevat meer dan 40 gevierde SEGA-klassiekers in een pakket. Daarmee is dit de grootste collectie first-partygames van SEGA ooit.

- Alex Kidd in the Enchanted Castle
- Alien Storm
- Altered Beast
- Beyond Oasis/The Story of Thor
- Bonanza Bros.
- Columns
- Comix Zone
- Decap Attack
- Dr. Robotnik's Mean Bean Machine
- Dynamite Headdy
- Ecco the Dolphin
- Ecco: The Tides of Time
- ESWAT: City Under Siege
- Fatal Labyrinth
- Flicky
- Gain Ground
- Golden Axe
- Golden Axe II
- Golden Axe III
- Kid Chameleon
- Phantasy Star II
- Phantasy Star III: Generations of Doom
- Phantasy Star IV: The End of the Millennium
- Ristar
- Shining Force: The Legacy of Great Intention
- Shining Force II: The Ancient Seal
- Shining in the Darkness
- Shinobi III: Return of the Ninja Master
- Sonic & Knuckles
- Sonic the Hedgehog
- Sonic the Hedgehog 2
- Sonic the Hedgehog 3
- Sonic 3D Flickies Island/Blast
- Sonic Spinball
- Streets of Rage
- Streets of Rage 2
- Streets of Rage 3
- Super Thunder Blade
- Vectorman
- Vectorman 2

Unlockable games:

- Alien Syndrome (arcade)
- Altered Beast (arcade)
- Congo Bongo (arcade) (under original title "Tip Top" in some regions)
- Fantasy Zone (arcade)
- Golden Axe Warrior (Sega Master System)
- Phantasy Star (Sega Master System)
- Shinobi (arcade)
- Space Harrier (arcade)
- Zaxxon (arcade)